Biological significance of maturation-and aging-related changes in environmental adaptability

成熟和衰老相关的环境适应性变化的生物学意义

• 批准号: 16207022
• 负责人: INOUE Yoshimitsu
• 金额: $ 30.45万
• 依托单位: Osaka International University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16207022/
• 关键词: older men; boys; whole body coordination; environmental adaptability; sweating response; skin blood flow; artery blood flow; non-thermal heat loss response; 膝伸展運動; 超音波ドプラー量; 大腿動脈血流; 総発汗量; 直腸温; 下肢温浴; イオントフォレーシス; 発汗量; 超音波ドプラー; 皮膚温度感覚; 単一汗腺

This research project addressed the ways in which environmental adaptability change with maturation and aging from the viewpoint of whole body coordination. Our cross-sectional and longitudinal (for 10 yrs) findings suggest that age-related decrement in heat loss effector function may involve cutaneous vasodilation, sweat output per gland, and active sweat gland density in that order. The successive decrement may proceed from the lower limbs to the back of the upper body, the front of the upper body, then the upper limbs and finally to the head. From results of heat-and acetylcholine-induced (including axon reflex) sweating tests, and skin thermal sensitivity test in the same older and younger men, we also discovered that the age-related decrement of thermoregulatory mechanisms may involve the skin thermal sensitivity, the cholinergic sensitivity of sweat glands, and the activities of the central sudomotor and sympathetic nerves in that order. Furthermore, our results of femoral artery … More blood flow and other measurements during passive heating and knee extension exercise suggest that the age-related decrement in the peripheral circulation (skin blood flow) may precede that in the central circulation (artery blood flow). Our data during isometric handgrip (IH) exercise in hot condition suggest that non-thermal heat loss responses decline with aging and the declines may be similar to those of thermal heat loss responses in the order of aging process.The data of sweating and rectal temperature during sports activity in summer suggested that prepubertal boys have an underdeveloped sweating function. The data during the heat stress (air temperature (T_a) was linearly increased from 28℃ to 40℃ over 60 min) suggested that compared with young men, prepubertal boys manifest greater physiological and perceptual strain under heat stress induced by T_a exceeding mean skin temperature, which is most probably attributable to a combination of lower evaporative heat loss, as evidenced by lower SR, and greater heat gain owing to a larger surface area-to-mass ratio. Our data during IH exercise suggest that prepubertal boys have underdeveloped non-thermal heat loss responses (remarkably in sweating rather than cutaneous vasodilation) and the underdeveloped responses may be similar to those of thermal heat loss responses in the order of maturation process. Less

该研究项目从全身协调的角度探讨了环境适应性随着成熟和衰老而变化的方式。我们的横截面和纵向（10年）的研究结果表明，年龄相关的热损失效应器功能的递减可能涉及皮肤血管舒张，每个腺体的汗液输出，并积极的汗腺密度在该顺序。这种连续的递减可以从下肢进行到上身的后部，上身的前部，然后上肢，最后到头部。从热和乙酰胆碱诱发（包括轴突反射）出汗试验和皮肤热敏感性试验的结果中，我们还发现，与年龄有关的体温调节机制的降低可能依次涉及皮肤热敏感性、汗腺胆碱能敏感性、中枢催汗神经和交感神经的活动。此外，我们的结果股动脉 ...更多信息 在被动加热和膝盖伸展运动期间的血流量和其它测量表明，外周循环（皮肤血流量）中与年龄相关的减少可能先于中央循环（动脉血流量）中的减少。热条件下等长握力（IH）运动的数据表明，非热性热损失反应随年龄增长而下降，其下降趋势与热性热损失反应的下降趋势相似;夏季运动中出汗和直肠温度的数据表明青春期前男孩的出汗功能不发达。热应激期间的数据（空气温度（T_a）在60 min内从28℃线性升高到40℃）表明，与青年男性相比，青春期前的男孩在T_a超过平均皮肤温度引起的热应激下表现出更大的生理和感知应变，这很可能归因于较低的蒸发热损失，如较低的SR，并且由于较大的表面积与质量比而获得更大的热增益。我们的数据在IH运动表明，青春期前的男孩有欠发达的非热热损失的反应（显着出汗，而不是皮肤血管舒张）和欠发达的反应可能是类似的热损失的反应，在成熟过程中的顺序。少

项目成果

Heat loss effector function in men and women of all ages.

所有年龄段男性和女性的热损失效应功能。

• 发表时间: 2005
• 期刊: Japanese Journal of Perspiration Research (JJPR) (in Japanese) 12(2)
• 作者: Inoue Y;Kuwahara T
• 通讯作者: Kuwahara T

Sex-and menstrual cycle-related differences in thermoregulation.

与性别和月经周期相关的体温调节差异。

• 发表时间: 2004
• 期刊: Taiiku-no-Kagaku (in Japanese) 54(10)
• 作者: Inoue Y;Kuwahara T;Ogura Y;Kondo N
• 通讯作者: Kondo N

Changes in blood flow in a conduit artery and superficial vein of the up per arm during passive heating in humans

人体被动加热过程中上臂导管动脉和浅静脉血流的变化

• 发表时间: 2007
• 期刊: Eur J Appl Physiol 101
• 作者: Ooue A;Ichinose KT;Shamsuddin AKM;Inoue Y;Nishiyasu T;Koga S;Kondo N
• 通讯作者: Kondo N

Effects of menstrual cycle and physical training on heat loss responses during dynamic exercise at moderate intensity in a temperate environment

• DOI: 10.1152/ajpregu.00547.2004
• 发表时间: 2005-05-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
• 影响因子: 2.8
• 作者: Kuwahara, T;Inoue, Y;Kondo, N
• 通讯作者: Kondo, N

Effect of skin temperature on the ion reabsorption capacity of sweat glands during exercise in humans

人体运动时皮肤温度对汗腺离子重吸收能力的影响

• 发表时间: 2005
• 期刊: Eur J Appl Physiol 94・4
• 作者: T. Okano;et. al.;森田 正文;Shamsuddin AKM et al.
• 通讯作者: Shamsuddin AKM et al.