Regulation of lymphocyte development by Notch/RBP-J signaling

为了阐明Notch/RBP-J信号在T细胞发育中的作用，我们分析了RBP-J条件性基因敲除小鼠，发现Notch/RBP-J信号负向调节γδT细胞的生成，另一方面促进胸腺中βT细胞的成熟。我们还证明了Notch/RBP-J信号增强了外周的Th2反应。此外，通过对Notch/RBP-J信号的内源性抑制物Mint的分析，我们发现Notch/RBP-J信号负性调节胸腺细胞的早期分化，Mint在胸腺T细胞发育和脾B细胞分化中抑制Notch/RBP-J信号。我们还报道了Mint对出生后脑神经细胞存活的调节作用。

To elucidate the functions of Notch/RBP-J signaling in T cell development, we analyzed RBP-J-conditional knockout mice and reported that Notch/RBP-J signaling negatively regulates γ δ T cell generation, on the other hand, it promotes a β T cell maturation in thymi. We also demonstrated that Notch/RBP-J signaling enhances Th2 response in the periphery. Moreover, by analyzing Mint, an endogenous inhibitor of Notch/RBP-J signaling, knockout mice, we demonstrated that Notch/RBP-J signaling negatively regulates early thymocyte differentiation and that Mint suppresses the Notch/RBP-J signaling in thymic T cell development and in splenic B cell differentiation. We also reported that Mint regulates neuronal cell survival in postnatal brain.