Regulation of lymphocyte development by Notch/RBP-J signaling

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To elucidate the functions of Notch/RBP-J signaling in T cell development, we analyzed RBP-J-conditional knockout mice and reported that Notch/RBP-J signaling negatively regulates γ δ T cell generation, on the other hand, it promotes a β T cell maturation in thymi. We also demonstrated that Notch/RBP-J signaling enhances Th2 response in the periphery. Moreover, by analyzing Mint, an endogenous inhibitor of Notch/RBP-J signaling, knockout mice, we demonstrated that Notch/RBP-J signaling negatively regulates early thymocyte differentiation and that Mint suppresses the Notch/RBP-J signaling in thymic T cell development and in splenic B cell differentiation. We also reported that Mint regulates neuronal cell survival in postnatal brain.