Stabilized peptide targeting programmed death-ligand 1 for Positron Emission Tomography imaging and cancer immunotherapy

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I developed a native peptide-based PET tracer for imaging tumor PD-L1 for the first time. I labeled the peptide with 18F and 64Cu. Moreover, the peptide was pegylated to form PEG-peptide conjugates via an optimum ‘one-pot’ strategy. The as-made radiotracers were evaluated for stability and specificity in vitro and imaged in normal mice and in a tumor model. As consequence, the 64Cu labeled compounds showed preferable imaging potential in vivo. Furthermore, the pegylation was demonstrated to change the pharmacokinetics and biodistribution of the tracers. Our studies suggested that native peptide-based tracers are capable of PD-L1 imaging, further improvement of the performance via rational design and exactly under current investigation.These results were published in Chem Commun.