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Therapeutic Strategy for Diabrtes mellitus by Hepatic Stem cell

肝干细胞治疗糖尿病的策略

基本信息

批准号：
19209045
负责人：
TAKAYAMA Tadatoshi
金额：
$ 30.95万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2009
项目状态：
已结题

项目摘要

The development of effective immunosuppressants has dramatically improved both graft and patient survival rates in organ transplantation, and has contributed to advances in medical transplantation during the past few years. Inducing donor-specific tolerance (DST) is widely believed to be the most effective solution to these problems. Chimerism is viewed as an attractive approach to inducing DST, and many studies of this phenomenon have been published. A mixed chimera can be created by transplanting bone marrow (BM) from histoincompatible donor mice to lethally-irradiated recipient mice, together with BM that is histocompatible with the recipient mice, so that the recipient haematopoietic cells can be partially replaced by donor-compatible cells. Compared to an allochimera, a mixed chimera is more stable and less susceptible to the lethal BM aplasia associated with BM graft rejection. We have focused on using splenocytes as a source of cells for establishing tolerance, in view of their availability for use in clinical practice. Splenocytes are an attractive source of cells with which to develop chimerism because they are a rich source of lymphocytes. In the current study, we verified the hypothesis that splenocytes containing abundant immunocytes are effective for maintaining chimerism and improving long-term graft survival in mice.

有效免疫抑制剂的开发极大地提高了器官移植中的移植物和患者的存活率，并在过去几年中促进了医学移植的进步。人们普遍认为诱导供体特异性耐受（DST）是解决这些问题的最有效方法。嵌合现象被认为是诱导 DST 的一种有吸引力的方法，并且已经发表了许多关于这种现象的研究。通过将组织不相容的供体小鼠的骨髓（BM）以及与受体小鼠组织相容的骨髓（BM）移植到经致死照射的受体小鼠中，可以产生混合嵌合体，从而使受体的造血细胞可以被供体相容的细胞部分替代。与异种嵌合体相比，混合嵌合体更稳定，并且不易受到与骨髓移植排斥相关的致命性骨髓发育不全的影响。鉴于脾细胞可用于临床实践，我们重点关注使用脾细胞作为建立耐受性的细胞来源。脾细胞是产生嵌合的有吸引力的细胞来源，因为它们是淋巴细胞的丰富来源。在当前的研究中，我们验证了这样的假设：含有丰富免疫细胞的脾细胞可有效维持嵌合状态并提高小鼠移植物的长期存活率。

项目成果

期刊论文数量（48）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Complete remission by chemotherapy in stage IE-IIE primary gastric lymphoma

IE-IIE期原发性胃淋巴瘤化疗完全缓解

DOI：
发表时间：
2007
期刊：
Hepato-Gastroenterology 54・76
影响因子：
0
作者：
Hasan MK;Komoike Y;Tsunesumi S;Nagao H;Nakao R;Matsuoka R;Kawaguchi N;池川志郎;Kochi M
通讯作者：
Kochi M

Characteristics of ecotopic pancreas in dynamic dadolinium-enhanced MRI

异位胰腺的动态达啉增强MRI特征