Advanced Molecular Transformations by Organ catalysts Based on Molecular Recognition

基于分子识别的器官催化剂的高级分子转化

• 批准号: 20245021
• 负责人: TERADA Masahiro
• 金额: $ 31.53万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20245021/
• 关键词: 触媒; 分子変換; 不斉合成; 環境調和; 水素結合; 分子認識; リン酸; 不斉触媒; 有機分子触媒

The activation of a substrate by means of a Bronsted acid and base is the most straightforward and common approach used to promote a reaction and hence Bronsted acids and bases have been widely utilized as efficient catalysts for a number of organic transformations. The development of novel Bronsted acid and base catalysts has been continuously studied due to their broad synthetic applicability. In the past decade, innovative research on Bronsted acid catalysis has enabled great progress. Specifically, research has focused on ' chiral Bronsted acid or base catalysis', in which enantioenriched products are obtained using a catalytic amount of a chiral organic molecule bearing an acidic or basic functionality. In our continuous studies on the cultivation of efficient and selective transformations using chiral Bronsted acids and bases, we successfully developed novel chiral Bronsted acids and several enantioselective transformations.

通过Bronsted酸和碱活化底物是促进反应最直接和最常用的方法，因此Bronsted酸和碱已被广泛用作许多有机转化的高效催化剂。新型Bronsted酸碱催化剂因其广泛的合成适用性而不断得到研究。近十年来，对Bronsted酸催化的创新研究取得了很大进展。具体来说，研究集中在“手性Bronsted酸或碱催化”上，其中使用具有酸性或碱性功能的手性有机分子的催化量获得对映体富集产物。在我们对利用手性Bronsted酸和碱进行高效选择性转化的持续研究中，我们成功地开发了新的手性Bronsted酸和几种对映选择性转化。

项目成果

Enantioselective Transformations via Activation of Electron-Rich Double Bonds Using Chiral Phosphoric Acids

使用手性磷酸激活富电子双键进行对映选择性转化

• 发表时间: 2011
• 作者: Arai;T.; Ogino;Y.;M. Terada
• 通讯作者: M. Terada

触媒調整ハンドブック第4編均一系触媒(13章)(有機触媒)(監修岩本正和)

催化剂制备手册第4卷均相催化剂（第13章）（有机催化剂）（岩本正和指导）

• 发表时间: 2011
• 作者: 土屋敬広;青山亮;佐久間理子;溝呂木直美;赤阪健;Dirk M. Guldi;加藤立久;永瀬茂;寺田眞浩
• 通讯作者: 寺田眞浩

Chiral Amine Synthesis, Methods, Developments and Applications(3章)(Enantioselective Synthesis of Amines by Chiral Bronsted Acid Catalysts-分担)(T.C.Nugent Ed.:)

手性胺的合成、方法、进展和应用（第三章）（手性布朗斯台德酸催化剂对映选择性合成胺-分享）（T.C.Nugent Ed.:）

• 发表时间: 2010
• 作者: Masahiro Terada;Norie Momiyama
• 通讯作者: Norie Momiyama

Chiral Bronsted Acid Catalysis for Enantioselective Hosomi-Sakurai Reaction of Imines with Allyltrimethylsilane

• DOI: 10.1021/ol200595b
• 发表时间: 2011-04-15
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Momiyama, Norie;Nishimoto, Hayato;Terada, Masahiro
• 通讯作者: Terada, Masahiro

Enantioselective Carbon-Carbon Bond Forming Reactions Catalyzed by Chiral Phosphoric Acids

手性磷酸催化的对映选择性碳-碳键形成反应

• 发表时间: 2013
• 作者: Nobuya Hiroshiba;Kenta Morimoto;Ryoma Hayakawa;Yutaka Wakayama Tatsuo Mori;Kiyoto Matsuishi;M. Terada
• 通讯作者: M. Terada