Constructive research for understanding the effects of amyloid β to neuronal function.

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Alzheimer's disease (AD) is characterized by the aggregation of amyloid β peptide (Aβ). The aim of this study is to investigate the effect of Amyloid Beta toxicity in embryonic rat hippocampus through chronic monitoring of neuronal cell electrical activity using multielectrode array (MEA) recordings, and the molecules protecting neurons from Aβ toxicity. Applying Aβ to cultured embryonic rat hippocampal neurons has an inhibitory effect on spontaneous activity started 24h after applying and the firing disappeared at 72h. When thymoquinone (TQ) active constituent of Nigella Sativa Oil and Aβ were simultaneously applied, thymoquinone reduces the deleterious effect of Aβ at 34h after applying. This results indicated that TQ have the potential protecting hippocampus cells from Aβ toxicity.