Preparation of chitosan microspheres for the medical application

点击翻译按钮获取中文摘要

In this study, Porous particles and capsules were prepared to recover of the damaged human tissues. Chitosan and γ-glycidoxypropyltrymethoxysilane (GPTMS) were used as the starting materials. Porous particles were prepared by dropping precursor sol with CaCl_2 or without into liquid nitrogen. Obtained porous particles had about 2 mm in diameter and 10-30μm in pore size. HAp particles of about 1μm in diameter deposited on the pore surface by soaking thus obtained hybrid parties in 0.01 M Na2HPO4 solution at 80℃ for 7 days. Bovine serum albumin (BSA) adsorbed much on the chitosan-GPTMS particles. Capsules were prepared by dropping carboxymethylcellulose into chitosan-GPTMS sols. The releasing of bioactive molecules included into the capsules was controlled by the cross-linking degree. Moreover the capsules did not show the cytotoxicity.