Control mechanisms of angiogenesis in the developing corpus luteum in the cow : local regulation by VEGF-Vasohibin

妊娠的建立是物种保存策略的基本现象。在哺乳动物中，黄体释放的黄体酮对妊娠具有关键作用。本研究的目的是阐明牛黄体发育的分子机制，并展望提高牛受胎率的技术发展方向。此外，在体外细胞培养模型中，血管紧张素转换酶刺激血管生成素的表达，而血管生成素抑制血管生成。这些发现表明，在奶牛发育中的黄体中，血管抑制素在适当水平下具有控制血管生成的潜力。

Establishment of pregnancy is basic phenomenon for the conserved strategy of species. In mammals, progesterone released from the corpus luteum has key role to establish pregnancy. The aim of the present study is the elucidation of molecular mechanisms about development of the bovine corpus luteum, and the presentation a vision of developing technologies for improvement of conception rate in the cow.From the results of the present study, we clearly demonstrated that VEGF-Vasohibin system exists in the bovine corpus luteum. Also, VEGF stimulated vasohibin expression and vasohibin inhibited angiogenesis induced by VEGF in vitro cell culture model. These findings suggest that vasohibin has a potential to control angiogenesis with the proper level in the developing corpus luteum in the cow.