Trans-generational"memory" in Drosophila innate immunity

为了验证先天免疫中是否存在“跨代记忆”，我们以果蝇为模型系统，进行了世代感染实验。基因表达谱分析表明，一些先天免疫相关的基因表达模式，在细菌感染的反应是显着不同的测试组，已感染的前几代和对照组之间没有感染以前。研究结果表明，只有先天免疫的生物体可以“记忆”环境压力，并且这种“记忆”可以跨代保持。

To examine the existence of"trans-generational memory" in innate immunity, we used Drosophila melanogaster as a model system and did generational infection experiments. Gene expression profiling analyses revealed that some innate immunity-related gene expression patterns in response to a bacteria infection is significantly different between test group that has been infected at previous generations and the control group not infected previously. The results suggest the possibility that organism which only has innate immunity can"memorize" environmental stress, and that the"memory" can be maintained across generations.