Characterization of the molecular mechanism of Ebolavirus entry into host cells.

埃博拉病毒进入宿主细胞的分子机制的表征。

• 批准号: 21890005
• 负责人: NANBO Asuka
• 金额: $ 1.7万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890005/
• 关键词: エボラウイルス; 宿主因子; エンドサイトーシス; 感染症

We characterized the multiple host factors involved in actin reorganization play roles in the internalization of Ebolavirus viral particles. We also found that the internalization of viral particles was associated with actin-dependent membrane ruffling, suggesting that Ebolavirus particles are internalized in the identified host factors-dependent manner.

我们表征了参与肌动蛋白重组的多种宿主因子在埃博拉病毒颗粒的内化中发挥作用。我们还发现病毒颗粒的内化与肌动蛋白依赖性膜皱褶相关，表明埃博拉病毒颗粒以确定的宿主因子依赖性方式内化。

项目成果

Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells

• DOI: 10.1111/j.1349-7006.2010.01842.x
• 发表时间: 2011-04-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Ikeda, Osamu;Mizushima, Akihiro;Matsuda, Tadashi
• 通讯作者: Matsuda, Tadashi

HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A.

• DOI: 10.1016/j.bbrc.2008.12.132
• 发表时间: 2009-02
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: S. Togi;Shinya Kamitani;S. Kawakami;O. Ikeda;R. Muromoto;A. Nanbo;T. Matsuda

BS69 negatively regulates the canonical NF-kB activation induced by Epstein-Barr virus-derived LMP1.

BS69 负向调节 Epstein-Barr 病毒衍生的 LMP1 诱导的典型 NF-kB 激活。

• 发表时间: 2009
• 期刊: FEBS Lett 583
• 作者: Ikeda;O;Sekine Y;Mizushima A;Oritani K;Yasui T;Fujimuro M;Muromoto R;Nanbo A;Matsuda T
• 通讯作者: Matsuda T

Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner.

• DOI: 10.1371/journal.ppat.1001121
• 发表时间: 2010-09-23
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Nanbo A;Imai M;Watanabe S;Noda T;Takahashi K;Neumann G;Halfmann P;Kawaoka Y
• 通讯作者: Kawaoka Y

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