Exploring the kinase-independent role of IKKβ

探索 IKKβ 的激酶独立作用

• 批准号: 21890115
• 负责人: ASHIDA Noboru
• 金额: $ 1.7万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890115/
• 关键词: 炎症; 循環器

We have identified several proteins which physically interact with IKKβ and they are possibly regulated by it in kinase-independent manner. Also we have found some proteins which have been reported to have close connection with atherosclerosis or cancer are regulated by some anti-inflammatory drugs.

我们已经鉴定了几种与IKKβ发生物理相互作用的蛋白质，它们可能以激酶非依赖性方式受IKKβ调节。另外，我们还发现一些与动脉粥样硬化或癌症密切相关的蛋白质受某些抗炎药物的调节。

项目成果

Exploring the role of IKKβ

探索 IKKβ 的作用

• 发表时间: 2010
• 作者: Nishino K.;Hayashi-Nishino M.;Yamaguchi A.;芦田昇
• 通讯作者: 芦田昇

IKK β regulates Akt activation in kinase-independent manner in endothelial cells

IKK β 在内皮细胞中以不依赖于激酶的方式调节 Akt 激活

• 发表时间: 2009
• 作者: Noboru Ashida;Sucharita SenBanerjee;Shohta Kodama;Joel A.Spencer;Parisa Zamiri;Ling Li;Robert E.Gerszten;Charles P.Lin;Michael Karin;Anthony Rosenzweig;Masayuki Yokode.
• 通讯作者: Masayuki Yokode.

IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways.

• DOI: 10.1038/ncomms1317
• 发表时间: 2011
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Ashida, Noboru;SenBanerjee, Sucharita;Kodama, Shohta;Foo, Shi Yin;Coggins, Matthew;Spencer, Joel A.;Zamiri, Parisa;Shen, Dongxiao;Li, Ling;Sciuto, Tracey;Dvorak, Ann;Gerszten, Robert E.;Lin, Charles P.;Karin, Michael;Rosenzweig, Anthony
• 通讯作者: Rosenzweig, Anthony