Analysis of periostin isoform expressed uniquely in periodontal ligament tissue

我们能够从牙周膜中唯一表达的Periostin亚基(PDL-Postin)和腺病毒感染的全长Periostin蛋白(Full-Postin)中获得非常高纯度的Periostin。使用这两种纯化的蛋白，我们发现PDL-POSSIN对整合素αvβ3的亲和力高于全POSTIN。这些结果提示，PDL-Postin可能在牙周组织的动态平衡机制和再生中起重要作用。

We were enable to collect very high purity both periostin isofrom uniquely expressed in periodontal ligament (PDL-POSTIN) and full length periostin proteins (FULL-POSTIN) with adenovirus infection. Using these both purified proteins, we have found that affinity to Integrin αvβ3 of PDL-POSTIN is higher than that of FULL-POSTIN. These results suggest that PDL-POSTIN may have an important role in homeostatic mechanism and regeneration of periodontal tissue.