Analysis of periostin isoform expressed uniquely in periodontal ligament tissue

我们能够在腺病毒感染的牙周膜中收集到非常高纯度的独特表达的骨膜蛋白（PDL-POSTIN）和全长骨膜蛋白（full - postin）。使用这两种纯化蛋白，我们发现PDL-POSTIN对整合素αvβ3的亲和力高于FULL-POSTIN。这些结果提示pdl - postn可能在牙周组织的稳态机制和再生中起重要作用。

We were enable to collect very high purity both periostin isofrom uniquely expressed in periodontal ligament (PDL-POSTIN) and full length periostin proteins (FULL-POSTIN) with adenovirus infection. Using these both purified proteins, we have found that affinity to Integrin αvβ3 of PDL-POSTIN is higher than that of FULL-POSTIN. These results suggest that PDL-POSTIN may have an important role in homeostatic mechanism and regeneration of periodontal tissue.