Novel treatment strategy of type 2 diabetes focused on beta cell mass

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We investigated the effect of glucokinase activator (GKA) on beta cell function and proliferation. Glucokinase activation by GKA increased expression levels of IRS-2 and cell cycle signaling molecules. GKA was able to stimulate beta cell proliferation independently of insulin stimulation and stimulate beta cell function independently of IRS-2. Also, our results raise the possibility that GKA do not work well under excessive oxidative stress in beta cells.