Regulation mechanisms of the placental barrier for the maintenance of the fetal environment and their relevancies to the phenotype

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The placental barrier regulates fetal transfer of maternal substances and thus maintains fetal environment. Therefore, it is important to elucidate functional regulations at the placental barrier. In this study, we clarified regulations of transporter expression at the placental barrier by (1) differentiation to the placental barrier, (2) gestational diabetes, and (3) caloric restriction. These results represent that the molecular expression at the placental barrier are regulated by placental differentiation and maternal nutrition environment in order to maintain fetal environment.