To clarify the molecular mechanism of novel therapeutic agent which suppresses bone resorption through inhibits noncanonical Wnt signaling.

我们以前曾报道过非典型的Wnt信号促进了破骨细胞的形成。为了阐明非规范的Wnt信号在破骨细胞发生中的作用，我们产生了破骨细胞前体特异性的Ror2，这是非规范的Wnt受体缺陷小鼠之一。由于破骨细胞前体中RANK的表达被抑制，这些小鼠表现出破骨细胞生成受损，这表明非规范的Wnt信号通过RANK表达增强了破骨细胞的生成。

We have previously reported that noncanonical Wnt signaling enhanced osteoclastogenesis. To clarify the role of noncanonical Wnt signaling in osteoclastogenesis, we generated osteoclast precursor-specific Ror2, one of the noncanonical Wnt receptor,-deficient mice. These mice exhibited impaired osteoclastogenesis due to suppression of RANK expression in osteoclast precursors, indicating that noncanonical Wnt signaling enhances osteoclastogenesis through RANK expression.