Involvement of TRPC channels in sympathetically-regulated bone metabolism

采用膜片钳技术，观察去甲肾上腺素对人成骨细胞SAM-1离子通道的影响。结果表明，去甲肾上腺素通过α1B-肾上腺素能受体抑制K通道。这种作用不受蛋白激酶C和细胞内钙离子浓度的影响。提示G_q蛋白偶联受体不参与这一作用。这项研究将有助于我们理解交感神经系统调节骨代谢的机制。

By using patch clamp methods, effects of noradrenaline on ion channels were investigated in human osteoblast, SaM-1. The results in this study indicated that noradrenaline inhibited K channels via α1B-adrenergic receptors. The effect was independent of protein kinase C and intracellular Ca^<2+> concentration. This suggested that G_q protein-coupled receptor was not involved in the effect. This study will aid our understanding of the mechanism behind the regulation of bone metabolism by the sympathetic nervous system.