Mechanism of neurotoxicity induced by oseltamivir and NSAIDs under the inflammatory conditions

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Oseltamivir and NSAIDs are used in the treatment of influenza. Neurotoxicity such as abnormal behavior and encephalopathy has been reported in influenza patients prescribed their drugs. The purpose of the present study is to examine the blood-brain barrier (BBB) permeability of oseltamivir or NSAIDs under inflammatory conditions. In this study, we demonstrated that (1) novel in vitro BBB models reflecting inflammation were developed, (2) brain pericytes released MMP-9 which may be responsible for BBB dysfuction induced by inflammation, (3) the BBB permeability of dicrofenac sodium salts was not changed under inflammatory conditions.