Elucidation of the mechanism of steatohepatitis-related cardiomyopathy due to dietary 7-ketocholesterol

阐明膳食 7-酮胆固醇导致脂肪性肝炎相关心肌病的机制

• 批准号: 21K20870
• 负责人: Chang Jiuyang
• 金额: $ 2万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-08-30 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K20870/
• 关键词: 心筋症; 7-ケトコレステロール; 脂肪肝炎; 糖尿病; 7-ketocholesterol; steatohepatitis; cardiac dysfunction; diabetes; cardomyopathy; oxysterol; NAFLD; cardiomyopathy; inflammation

项目成果

Steatohepatitis-related Atherosclerosis and/or Cardiomyopathy in a Rodent Model

啮齿动物模型中脂肪性肝炎相关的动脉粥样硬化和/或心肌病

• 发表时间: 2021
• 作者: Koseki M;Kanno K;Chang J;Saga A;Okada T;Inui H;Tanaka K;Omatsu T;Higo T;Ide S;Saito S;Kamada Y;Ohama T;Nishida M;Yamashita S;Sakata Y
• 通讯作者: Sakata Y

A Case with Sitosterolemia Accompanied with Macrothrombocytopenia and Bilateral Elbow Tuberous Xanthomas

谷甾醇血症伴巨血小板减少及双侧肘部结节性黄瘤一例

• 发表时间: 2021
• 作者: Takeshi Okada;Masahiro Koseki;Hisashi Kato;Koichi Tomita;Katsunao Tanaka;Jiuyang Chang;Hiroyasu Inui;Kotaro Kanno;Ayami Saga;Tohru Ohama;Takeshi Kujiraoka;Hiroaki Hattori;Makoto Nishida;Shizuya Yamashita;Yasushi Sakata
• 通讯作者: Yasushi Sakata

XCR1+ Dendritic Cell-Induced CD4 T Helper-1 Activation Leads to Exacerbation of Remodeling after Myocardial Infarction

XCR1 树突状细胞诱导的 CD4 T Helper-1 激活导致心肌梗死后重塑加剧

• 发表时间: 2022
• 作者: Inui H;Nshida M;Asaji M;Ide S;Saito S;Okuzaki D;Matsui T; Ichii M;Saga A;Kanno K;Okada T;Koseki M;Ohama T;Yamashita S; Sakata Y
• 通讯作者: Sakata Y

Targeted Next-generation Sequencing of 36 Lipid-Related Genes in Patients with Clinically Diagnosed Familial Hypercholesterolemia

对临床诊断的家族性高胆固醇血症患者的 36 个脂质相关基因进行下一代靶向测序

• 发表时间: 2021
• 作者: Takeshi Okada;Masahiro Koseki;Makoto Nishida;Takashi Omatsu;Katsunao Tanaka;Hiroyasu Inui;Jiuyang Chang;Kotaro Kanno;Ayami Saga;Tohru Ohama;Mitsuaki Ishihara;Takeshi Kujiraoka;Hiroaki Hattori;Daisaku Masuda;Shizuya Yamashita;Yasushi Sakata
• 通讯作者: Yasushi Sakata

心筋梗塞後に活性化したXCR1+樹状細胞によるTh1の誘導がリモデリングの増悪につながる

心肌梗死后激活的XCR1+树突状细胞诱导Th1导致重构恶化

• 发表时间: 2021
• 作者: 乾洋勉;西田誠;朝治真澄;嵯峨礼美;冠野昂太郎;常久洋;朱頴広;岡田健志;田中克尚;大濱透;小関正博;山下静也;坂田泰史
• 通讯作者: 坂田泰史