DNA Nanoshuttles: A New Class of DNA-Binding Molecules

DNA 纳米梭：一类新型 DNA 结合分子

• 批准号: DP0557235
• 负责人: Prof Louis Rendina
• 金额: $ 35.39万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-31 至 2008-12-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557235
• 关键词: DNA; Nanoshuttles; New; Class; Binding

The interaction of molecules with DNA, the molecule that controls genetic information, is fundamental to drug design, diagnosis of disease and the environment. DNA-nanoshuttles are ring-shaped molecules that thread onto DNA and shuttle from one end to the other. This threading interaction is without precedent and hence DNA-nanoshuttles have significant potential applications in all areas of medicine, biotechnology and nanotechnology that involve DNA interactions. This research may lead to the design of new diagnostics and applications that will benefit the Australian community, and will provide excellent training of researchers in skills required for employment in the biotechnology and pharmaceutical fields.

分子与DNA（控制遗传信息的分子）的相互作用是药物设计、疾病诊断和环境的基础。DNA纳米梭是一种环形分子，可以穿在DNA上，从一端穿梭到另一端。这种穿线相互作用是没有先例的，因此DNA-纳米梭在涉及DNA相互作用的医学、生物技术和纳米技术的所有领域中具有重要的潜在应用。 这项研究可能会导致设计新的诊断和应用，这将有利于澳大利亚社会，并将提供良好的培训研究人员在生物技术和制药领域就业所需的技能。