Development of the cytoplasmic molecular delivery by the photodynamic treatment inducing the mild oxidation of the plasma membrane

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Photodynamic therapy(PDT) established as a curative treatment for the cancer has acquired anticancer efficacy by producing reactive oxygen species on theplasma membrane orthe cytoplasmic organelle. In this study, I employed PDT inducing no remarkable cell injury and investigate whether the PDT(1) can deliverthe macromoleculeto the cell,(2) can enhance the cytotoxic effect of the anticancer drug. As the results, the PDT would transfer a molecule of 10 kDa or less through the plasma membrane of the HeLa cells and enhance the cytotoxic effects of Bleomycin.