Identification of regulatory B cells in a murine model of primary biliary cirrhosis and fundamental examination for clinical application

原发性胆汁性肝硬化小鼠模型中调节性B细胞的鉴定及临床应用基础检查

• 批准号: 22890024
• 负责人: MORITOKI Yuki
• 金额: $ 1.96万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890024/
• 关键词: 原発性胆汁性肝硬変; B細胞; CD20; CD5

Location of CD5 expressing B cells, supposed to have a regulatory function in an inflammatory condition, was examined using immunohistochemical double staining for CD20 and CD5 in the liver samples from the patients of primary biliary cirrhosis and chronic hepatitis C. Both liver samples demonstrated CD20 and CD5 double-positive B cells in follicle-like aggregations in the portal areas, while B cells were CD5 negative in ductal invasion, suggesting unlikely contribution of CD20 and CD5 double-positive B cells directly to biliary epithelial damage in the livers of primary biliary cirrhosis.

应用免疫组化双染法检测了原发性胆汁性肝硬化和慢性丙型肝炎患者肝组织中表达CD 5的B细胞的位置，认为表达CD 5的B细胞在炎症状态下具有调节功能。两个肝脏样本均显示汇管区滤泡样聚集物中的CD 20和CD 5双阳性B细胞，而导管浸润中的B细胞为CD 5阴性，表明CD 20和CD 5双阳性B细胞不太可能直接导致原发性胆汁性肝硬化肝脏中的胆汁上皮损伤。

项目成果

CD45ROhighCD57+CD8high T cells in primary biliary cirrhosis

原发性胆汁性肝硬化中 CD45ROhighCD57 CD8high T 细胞

• 发表时间: 2011
• 作者: Masanobu Tsuda;Yoko Ambrosini;Yuki Moritoki;Katsunori Yoshida;Weici Zhang;Guo-Xiang Yang;Yugo Ando;Guanghua Rong;Toshio Nakatani;Christopher Bowlus;Aftab Ansari;Zhe-Xiong Lian;M. Eric Gershwin
• 通讯作者: M. Eric Gershwin

抗CD20抗体療法による自己免疫性胆管炎の改善および腸炎の増悪

抗CD20抗体治疗改善自身免疫性胆管炎和肠炎恶化

• 发表时间: 2010
• 作者: 守時由起;他
• 通讯作者: 他

Pathological features of new animal models for primary biliary cirrhosis.

• DOI: 10.1155/2012/403954
• 发表时间: 2012
• 期刊: International journal of hepatology
• 影响因子: 1.8
• 作者: Tsuneyama K;Moritoki Y;Kikuchi K;Nakanuma Y
• 通讯作者: Nakanuma Y

Disease course dependent opposite roles of B cells to pathogenesis and pathophysiology of autoimmune cholangitis in dnTGF-ssRII mice

dnTGF-ssRII 小鼠中 B 细胞对自身免疫性胆管炎发病机制和病理生理学的病程依赖性相反作用

• 发表时间: 2010
• 作者: Y.Moritoki;et al
• 通讯作者: et al

A critical role of B cells in biliary disease and sialadenitis in the NOD. c3c4 model of c3c4 model ofautoimmune chautoimmune cholangitis

B 细胞在 NOD 胆道疾病和唾液腺炎中发挥关键作用。

• 发表时间: 2011
• 作者: Yuki Moritoki;Masanobu Tsuda;Koichi Tsuneyama;Weici Zhang;Katsunori Yoshida;Zhe-Xiong Lian;Guo-Xiang Yang;William M. Ridgway Linda S.;Wicker;Aftab;A. Ansari;M. Eric Gershwin
• 通讯作者: M. Eric Gershwin