Identification of regulatory B cells in a murine model of primary biliary cirrhosis and fundamental examination for clinical application

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Location of CD5 expressing B cells, supposed to have a regulatory function in an inflammatory condition, was examined using immunohistochemical double staining for CD20 and CD5 in the liver samples from the patients of primary biliary cirrhosis and chronic hepatitis C. Both liver samples demonstrated CD20 and CD5 double-positive B cells in follicle-like aggregations in the portal areas, while B cells were CD5 negative in ductal invasion, suggesting unlikely contribution of CD20 and CD5 double-positive B cells directly to biliary epithelial damage in the livers of primary biliary cirrhosis.