Testifing the potentialities of organ transplantation from the donor with malignancy

测试患有恶性肿瘤的捐献者器官移植的潜力

• 批准号: 22890083
• 负责人: OHSAWA Ichiro
• 金额: $ 1.83万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890083/
• 关键词: 臓器移植; がん

Deoxyspergualin(DSG); immunosuppressive drug, exerts growth inhibitory effect on ACI derived rat renal cancer cell. Transplanted rat renal cancer cells on LEW skin under cyclosporin A administration showed rapid growth which leads to death from 30 to 54 days with multiple lung metastasis, but these cancer cells transplanted on LEW skin under DSG administration shows no growth during 60 days and all rats survived. These finding suggested the possibility of cancer cell elimination effect of DSG on organ transplantation from donors with malignancies.

脱氧精胺(DSG)是一种免疫抑制剂，对ACI来源的大鼠肾癌细胞具有生长抑制作用。环孢菌素A皮下移植的大鼠肾癌细胞生长迅速，30~54天死亡，并有多处肺转移，而DSG皮下移植的癌细胞在60天内无生长，全部存活。这些发现提示DSG在恶性肿瘤供者器官移植中具有消除癌细胞的作用。