Identification of biomarker and therapeutic target for lung cancer

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Immunohistochemical analysis showed that LASEP3 was over-expressed in lung cancers. In addition, a high level of LASEP3 expression was associated with poor prognosis for NSCLC patients. The proportion of serum LASEP3-positive cases was 61. 8% of NSCLCs, while 5. 5% of healthy volunteers were falsely diagnosed. Furthermore, treatment of lung cancer cells with siRNAs against LASEP3 suppressed its expression and resulted in growth suppression of the lung cancer cells. We have identified LASEP3 as a potential target for the development of diagnostic and prognostic biomarkers for lung cancer.