In Vivo Evaluation of Deep Structure of Optic Disc in Glaucoma Using Swept Source Optical Coherence Tomography

扫描光源光学相干断层扫描证实青光眼眼的筛板在垂直方向上比正常眼的筛板更呈W形，表明青光眼性视神经病变的筛板变形在活体内是可以观察到的。有颞侧巩膜前突者视野缺损明显多于无颞侧巩膜前突者。高度近视眼巩膜前突角度与前突上方RNFL厚度及视野严重程度显著相关。这些结果表明，部分高度近视眼受视乳头周围巩膜直接压迫或牵拉的影响。青光眼的深层结构改变和高度近视的视神经损害与视乳头周围巩膜改变有关。

The lamina cribrosa of glaucoma eyes was proved to be more vertically W-shaped than that of normal eyes by using swept source optical coherence tomography, which indicated that deformation of the lamina causing the glaucomatous optic neuropathy could be observed in vivo. Furthermore, the eyes with temporal scleral protrusion showed visual field defects more than those without. The angle of the scleral protrusion of high myopic eyes was significantly correlated to the RNFL thickness above the protrusion and the visual field severity. These indicate that some of the high myopias are affected by direct scleral compression or stretching at peripapillary region. Deep structural changes in glaucoma and peripapillary scleral changes in high myopia are related to the optic nerve damage.