An experimental studies of degenerative change of the articular cartilage induced by the joint immobilization and the effect of the joint motion

在这项研究中，我们研究了关节制动引起的关节软骨退变以及持续被动运动(CPM)对软骨退变的影响。制动后两周关节软骨变薄，四周后蛋白多糖含量下降。另一方面，在固定期内应用CPM可纠正关节制动引起的关节软骨退行性改变。此外，CPM还可抑制基质金属蛋白酶的升高和金属蛋白酶组织抑制物的降低。

In this study, we examined the degeneration of articular cartilage induced by joint immobilization and the effects of continuous passive motion(CPM) on cartilage degeneration. Immobilization resulted in thinning of the articular cartilage after two-week immobilization and loss of proteoglycan content after four-week immobilization. On the other hands, CPM applied for immobilization period rectified all degenerative changes induced by joints immobilization in the articular cartilage. Additionally, CPM inhibited the increase of Matrix metalloproteinases and the decrease of tissue inhibitor of metalloproteinase.