Functionalized capillary device for mass spectrometry-based subcellular lipid profiling

该项目的目的是开发一种毛细管装置，可以执行亚细胞脂质分析。该设备将允许微小采样，脂质纯化和分离，以及用于质谱（MS）分析的纳米电喷雾电离。我们的初步试验表明，实验室自制的毛细管装置可以用于标准的脂质质谱检测。该装置成功地实现了微小采样和纳米电喷雾电离，并将其集成到一个毛细管装置中。基于这一有希望的结果，我们计划将脂质纯化和分离的功能整合到毛细管装置中。

The objective of this project is to develop a capillary device that can perform subcellular lipid profiling. This device will allow for minute sampling, lipid purification and separation, and nano electrospray ionization for mass spectrometry (MS) analysis. Our preliminary tests have shown that a lab-made capillary device can be used for standard lipid MS detection. The device successfully achieved minute sampling and nano electrospray ionization, which have been integrated into a single capillary device. Building on this promising outcome, we plan to integrate the function for lipid purification and separation into the capillary device as well.