Analysis for endocannabinoid signaling in the epileptogenic circuit

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This research project reveled the molecular anatomical basis fora major endocannabinoid, 2-arachidonoyl glycerol (2-AG), to effectively inhibit synaptic transmission at mossy cell-granule cell synapses, which constitute a potentiaepilectogenic circuit in the CNS. This suggests that 2-AG plays a role as a synapticcircuit breaker to prevent the epiletogenesis.