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Understanding the molecular mechanism required for an anchorage-independent growth of CD133-positive ovarian cancer cells

Understanding the molecular mechanism required for an anchorage-independent growth of CD133-positive ovarian cancer cells
了解 CD133 阳性卵巢癌细胞非贴壁依赖性生长所需的分子机制
批准号:
23800055
负责人:
ARAKI Marito
金额:
$2.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
Solid tumors are comprised of heterogeneous cells, which seem to play crucial roles in the establishment of drug-resistance and the recurrence of tumor. In this study, we identified genes highly expressed in CD133-positive ovarian cancer cells, named themHEG(Highly-expressed genes in CD133-positive cells), and showed that HEG1-3 play an important role for the anchorage-independent cell growth. Further studies would reveal more precise molecular mechanisms of the anchorage-independent cell growth in CD133-positive ovarian cancer cells.
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