Exploring the mechanisms for adaptation to mechanical forces in theheart : Ca2+ handling and coronary microcirculation remodeling

探索心脏适应机械力的机制：Ca2处理和冠状动脉微循环重塑

• 批准号: 23800067
• 负责人: UJIHARA Yoshihiro
• 金额: $ 2.08万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23800067/
• 关键词: リモデリング; 心筋細胞; 心肥大; 心不全; カルシウム; Na+/Ca2+交換体; 機械的負荷; 冠微小循環; メカニカルストレス; 心機能; Ca2+ハンドリング; 血行動態負荷; カルシウム動態; 冠循環

The cardiac Na+/Ca2+ exchanger is the predominant mechanism for the extrusion of Ca2+ from beating cardiomyocytes. To investigate the role of the Na+/Ca2+ exchanger during progression of heart failure, I generated pressure-overload-induced left ventricular hypertrophy and dysfunction. The Na+/Ca2+ exchanger activity decreased as the cardiac function failed, suggesting that a decrease in the extrusion of cytoplasmic Ca2+ may cause heart failure.

心肌Na+/Ca ~（2+）交换器是搏动心肌细胞Ca ~（2+）排出的主要机制。为了研究Na+/Ca 2+交换在心力衰竭进展过程中的作用，我制作了压力超负荷诱导的左心室肥大和功能障碍。Na+/Ca ~（2+）交换活性随心功能衰竭而降低，提示细胞质Ca ~（2+）排出减少可能导致心力衰竭。

项目成果

Effects of Cytoskeletal Orientations on Deformation of a Cell Residing in a Collagen Gel Construct

细胞骨架方向对胶原凝胶构建体中细胞变形的影响

• DOI: 10.1299/jbse.7.2
• 发表时间: 2012
• 期刊: Journal of Biomechanical Science and Engineering
• 作者: Masanori Nakamura;Yoshihiro Ujihara;Masatsugu Soga;Kenichiro Koshiyama;Hiroshi Miyazaki;Shigeo Wada
• 通讯作者: Shigeo Wada

Contribution of actin filaments to the global compressive properties of fibroblasts

• DOI: 10.1016/j.jmbbm.2012.05.006
• 发表时间: 2012-10-01
• 期刊: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
• 影响因子: 3.9
• 作者: Ujihara, Yoshihiro;Nakamura, Masanori;Wada, Shigeo
• 通讯作者: Wada, Shigeo

Segmentation and morphometric analysis of cells from fluorescence microscopy images of cytoskeletons.

• DOI: 10.1155/2013/381356
• 发表时间: 2013
• 期刊: Computational and mathematical methods in medicine
• 作者: Ujihara Y;Nakamura M;Miyazaki H;Wada S
• 通讯作者: Wada S

発生段階の心筋細胞の分化・分裂機構の解明に向けた予備的解析

初步分析阐明心肌细胞发育过程中的分化和分裂机制

• 发表时间: 2013
• 作者: 橋本謙;氏原嘉洋;毛利聡
• 通讯作者: 毛利聡