Mathematical Modeling of BoneRemodeling Considering Cellular Metabolic Activity

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In the present study, we developed a mathematical model for bone remodeling incorporating the possible mechanism of osteocytes mechanosensing and the signaling cascade of bonecells in order to predict the structural changes in bone tissue from cellular metabolic activities. First, focusing on the process of mechanosensing by osteocytes, we investigated the deformation of a single osteocyte process in a canaliculus due to interstitial fluid flow. Then, we proposed a mathematical model for bone remodeling taking a representative cell signaling pathways into account and simulated the morphological changes in bone tissue to adapt to the mechanical environment.