Elucidation of immunological mechanisms in swine selected for resistance to Mycoplasmal pneumonia

本研究分析了为降低MPS引起的肺部病变的发病率而从基因上选择的一个新的猪品系的免疫表型。MPS选择的动物外周血单个核细胞对细菌相关成分刺激的反应性低于常规猪，体内淋巴细胞对MPS疫苗致敏的反应性也低于MPS选择的猪。同时，MPS选择的猪在疫苗致敏后产生的干扰素-g较高。这些免疫学特征被认为是减少MPS损害的重要因素。

The immunophenotype of a novel swine line genetically selected to reduce the incidence of pulmonary lesions caused by MPS was analyzed in this study. The reactivity of peripheral blood mononuclear cells stimulated with bacteria-associated component was lower in MPS selected animal rather than conventional pigs, and the reactivity of lymphocyte to MPS vaccine sensitization in vivo was also lower in the MPS selected pigs. Meanwhile, the induction of IFN-g was higher in MPS selected pigs after vaccine sensitization. These immunological characteristics are considered to be important for the reduction of MPS lesions