Elucidation of immunological mechanisms in swine selected for resistance to Mycoplasmal pneumonia

阐明抗支原体肺炎猪的免疫机制

• 批准号: 23880004
• 负责人: SHIMAZU Tomoyuki
• 金额: $ 2.08万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23880004/
• 关键词: 抗病性; ブタ; 免疫

The immunophenotype of a novel swine line genetically selected to reduce the incidence of pulmonary lesions caused by MPS was analyzed in this study. The reactivity of peripheral blood mononuclear cells stimulated with bacteria-associated component was lower in MPS selected animal rather than conventional pigs, and the reactivity of lymphocyte to MPS vaccine sensitization in vivo was also lower in the MPS selected pigs. Meanwhile, the induction of IFN-g was higher in MPS selected pigs after vaccine sensitization. These immunological characteristics are considered to be important for the reduction of MPS lesions

本研究分析了一种新的猪系的免疫表型，该猪系通过遗传选择来降低MPS引起的肺部病变的发生率。与常规猪相比，MPS选择的动物的外周血单核细胞对细菌相关组分刺激的反应性较低，MPS选择的猪的淋巴细胞对MPS疫苗致敏的体内反应性也较低。同时，疫苗致敏后MPS选择猪的IFN-γ诱导率较高。这些免疫学特征被认为是重要的减少MPS病变

项目成果

MPSワクチン刺激に対する抗病性選抜豚の末梢血中免疫細胞割合の比較

抗病猪外周血中 MPS 疫苗刺激后免疫细胞百分比的比较

• 发表时间: 2012
• 作者: 陸拾七;島津朋之;ら
• 通讯作者: ら

Changes in peripheral blood leukocytes in swine selected line for resistance to MPS

MPS抗性猪选系外周血白细胞的变化

• 发表时间: 2012
• 作者: T.Shimazu;J.Riku;Y.Katayama;M.Li;T.Sato;H.Kitazawa;H.Aso;K.Katoh;Y.Suda;A.Sakuma;M.Nakajoh;K.Suzuki
• 通讯作者: K.Suzuki

MPS選抜系統豚のMPSワクチンに対する獲得免疫応答の比較

MPS 筛选猪对 MPS 疫苗获得性免疫反应的比较

• 发表时间: 2012
• 作者: 片山雄貴;島津朋之;ら
• 通讯作者: ら

MPS 病変選抜種と末梢血免疫能選抜種豚の肺病変及び MPS ワクチン刺激に対する末梢血免疫応答の比較

MPS病变选育品种与外周血免疫功能健全选育品种对肺部病变和MPS疫苗刺激的外周血免疫反应比较

• 发表时间: 2013
• 作者: Shinsaku Ito;Mikihisa Umehara;Atsushi Hanada;Shinjiro Yamaguchi;Tadao Asami;島津朋之・陸拾七・片山雄貴・佐藤匠・大津良輔・遠藤雅士・北澤春樹・麻生久・加藤和雄・須田義人・佐久間晶子・中條満・鈴木啓一;Maho Yagi-Utsumi;加藤一幾;Shinsaku Ito;矢木-内海真穂;島津朋之，ら;陸拾七，島津朋之，ら
• 通讯作者: 陸拾七，島津朋之，ら

免疫能選抜豚の免疫応答・抗病性の検討

免疫功能健全的选定猪的免疫反应和抗病特性检查

• 发表时间: 2012
• 作者: Maho Yagi-Utsumi;Koichi Kato;陸拾七，島津朋之，ら
• 通讯作者: 陸拾七，島津朋之，ら