Risk-assessment of toxic components derived from biodiesel feedstockJatropha curcas.

生物柴油原料麻风树有毒成分的风险评估。

• 批准号: 23880028
• 负责人: MOTOYUKI Nakao
• 金额: $ 2.08万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23880028/
• 关键词: バイオディーゼル; ジャトロファ; 発癌プロモーター; 健康影響評価; 急性毒性; ホルボールエステル; 環境分析; 環境技術; バイオ燃料; リスク評価

Jatropha curcas, one of the biodiesel feedstock has been drawing spotlight as uncompetitive biological resources with edible plant because it is unfit for human consumption due to its toxic components. In this study, risk assessment of the phorbol ester (PE) isolated from Jatropha was carried out. High concentration of Jatropha PE showed severe acute toxicity in applied mice. Jatropha PE showed strong tumor promotion activity in transformation assay using cultured cells. However, lower concentration of PE did not develop any tumor in mice. These results suggested that Jatropha PE differentially behaved in vivo and in vitro.

作为生物柴油原料之一的小桐子因其有毒成分不适合人类食用，已成为与食用植物竞争的生物资源。在这项研究中，佛波醇酯（PE）从麻风树分离的风险评估进行。高浓度麻风树PE对小鼠有严重的急性毒性。麻风树PE在使用培养细胞的转化试验中显示出强的肿瘤促进活性。然而，较低浓度的PE在小鼠中不产生任何肿瘤。这些结果表明，麻风树PE在体内和体外的差异表现。

项目成果

久留米大学 医学部 公衆衛生学講座ホームページ内「研究概要」

久留米大学医学院公共卫生课程主页“研究概述”

Transdermal Toxicity of the Phorbol Ester Isolated from Biodiesel Feedstock, Jatropha Curcas.Society of Toxicology

从生物柴油原料麻疯树中分离出的佛波酯的经皮毒性。毒理学会

• 发表时间: 2013
• 作者: Motoyuki Nakao;Satoko Kinoshita;Yoko Ishihara.
• 通讯作者: Yoko Ishihara.

Transdermal toxicity of the phorbol ester isolated from biodiesel feedstock, Jatropha curcas

从生物柴油原料麻风树中分离出的佛波酯的经皮毒性

• 发表时间: 2013
• 作者: Abiko;T.;Kotula;L.;Shiono;K.;Malik;A.I.;Colmer;T.D.;Nakazono;M.;Motoyuki Nakao
• 通讯作者: Motoyuki Nakao