Risk-assessment of toxic components derived from biodiesel feedstockJatropha curcas.

点击翻译按钮获取中文摘要

Jatropha curcas, one of the biodiesel feedstock has been drawing spotlight as uncompetitive biological resources with edible plant because it is unfit for human consumption due to its toxic components. In this study, risk assessment of the phorbol ester (PE) isolated from Jatropha was carried out. High concentration of Jatropha PE showed severe acute toxicity in applied mice. Jatropha PE showed strong tumor promotion activity in transformation assay using cultured cells. However, lower concentration of PE did not develop any tumor in mice. These results suggested that Jatropha PE differentially behaved in vivo and in vitro.