Studies on health benefits, particularly anti-allergic effects, of algal polyphenols (phlorotannins) from brown algae

点击翻译按钮获取中文摘要

The condensed phlorotannin from a brown alga Eisenia arborea on allergic model mouse orally administered ovalbumin (allergen) exhibited the anti-allergic effects due to the improvement of immunity balance. When the experiment of mouse ear edema was carried out, four kinds of phlorotannins exhibited anti-inflammatory effects. When the intestinal absorption of the active compound (phlorotannin) was evaluated using Caco-2 cells that are the intestinal absorption model, about 5 % of phlorotannin was permeated. And, as anti-allergic compound, a kind of phlorotannin dieckol was isolated from the lipophilic fraction of E. arborea extract.About brown algae except for E. arborea, the extracts of Ecklonia kurome and E. stolonifera exhibited anti-allergic and anti-inflammatory effects. Moreover, a red alga Hypnea charoides was focused as minor edible seaweed, and the hot water extract of the seaweed exhibited anti-coagulant and hypocholesterolemic effects in rats.