Studies on health benefits, particularly anti-allergic effects, of algal polyphenols (phlorotannins) from brown algae

褐藻中的藻多酚（草单宁）的健康益处，特别是抗过敏作用的研究

• 批准号: 23880036
• 负责人: SUGIURA Yoshimasa
• 金额: $ 2.08万
• 依托单位: National Fisheries University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23880036/
• 关键词: 褐藻; アレルギー; 食品機能; 水産化学; 生理活性; フロロタンニン

The condensed phlorotannin from a brown alga Eisenia arborea on allergic model mouse orally administered ovalbumin (allergen) exhibited the anti-allergic effects due to the improvement of immunity balance. When the experiment of mouse ear edema was carried out, four kinds of phlorotannins exhibited anti-inflammatory effects. When the intestinal absorption of the active compound (phlorotannin) was evaluated using Caco-2 cells that are the intestinal absorption model, about 5 % of phlorotannin was permeated. And, as anti-allergic compound, a kind of phlorotannin dieckol was isolated from the lipophilic fraction of E. arborea extract.About brown algae except for E. arborea, the extracts of Ecklonia kurome and E. stolonifera exhibited anti-allergic and anti-inflammatory effects. Moreover, a red alga Hypnea charoides was focused as minor edible seaweed, and the hot water extract of the seaweed exhibited anti-coagulant and hypocholesterolemic effects in rats.

结果表明，从棕色木姜子中提取的浓缩根皮单宁经口给予卵清蛋白（变应原）对变态反应模型小鼠具有明显的抗变态反应作用，其机制可能与改善免疫平衡有关。在小鼠耳肿胀实验中，四种根皮单宁均表现出抗炎作用。当使用作为肠吸收模型的Caco-2细胞评价活性化合物（间皮单宁）的肠吸收时，约5%的间皮单宁渗透。同时，从E.对除E. arborea、Ecklonia kurome和E.匍匐茎具有抗过敏和抗炎作用。此外，一种红色的海藓被集中作为次要的食用海藻，并且该海藻的热水提取物在大鼠中表现出抗凝血和降低胆固醇的作用。

项目成果

褐藻ツルアラメ抽出物による抗アレルギー効果

褐藻提取物的抗过敏作用

• 发表时间: 2012
• 作者: Shinkuma S;Nishie W;Jacyk WK;Natsuga K;Ujiie H;Nakamura H;Akiyama M;Shimizu H.;杉浦義正
• 通讯作者: 杉浦義正

The Anticoagulant Activity and Hypocholesterolemic Effect of a Hot Water Extract from the Red Alga Ibaranori (<i>Hypnea charoides</i>)

红藻 Ibaranori (<i>Hypnea charoides</i>) 热水提取物的抗凝血活性和降胆固醇作用

• DOI: 10.3136/fstr.18.735
• 发表时间: 2012
• 期刊: Food Science and Technology Research
• 影响因子: 0.6
• 作者: 梶田美穂子;藤田恭之;楠田哲也ほか;杉浦義正
• 通讯作者: 杉浦義正

褐藻サガラメMIC抽出物の脂溶性画分から単離した抗アレルギー性成分

从褐藻 Sagarame MIC 提取物的脂溶性部分中分离出的抗过敏成分

• 发表时间: 2013
• 作者: 中沢威人;石内勘一郎;渡辺賢二;Fujima N;Mihoko Kajita;杉浦義正,田中竜介,松下映夫
• 通讯作者: 杉浦義正,田中竜介,松下映夫

褐藻サガラメM/C抽出物の脂溶性画分から単離した抗アレルギー性成分

从褐藻 Sagarame M/C 提取物的脂溶性部分中分离出的抗过敏成分

• 作者: Yamamoto K;Ohga N;Hida Y;Maishi N;Kawamoto T;Kitayama K;Akiyama K;Osawa T;Kondoh M;Matsuda K;Onodera Y;Fujie M;Kaga K;Hirano S;Shinohara N;Shindoh M;Hida K.;杉浦義正
• 通讯作者: 杉浦義正

Effect of ant-oxidative treatments on lipid oxidation in skinless fillet of Pacific saury Cololabis saira in frozen-storage

抗氧化处理对冻藏秋刀鱼去皮鱼片脂质氧化的影响

• DOI: 10.1111/j.1745-4549.2011.00652.x
• 发表时间: 2013
• 期刊: J. Food Process. Pres
• 作者: Tanaka R;Naiki K;Tsuji K;Nomata H;Sugiura Y;Matsushita T;Kimura I
• 通讯作者: Kimura I