Early diagnosis with in vivo laser confocal microscopy incytomegalovirus corneal endotheliitis and Acanthamoeba keratitis

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In this study, we performed in vivo laser confocal microscopic analysis in patients with cytomegalovirus corneal endotheliitis and Acanthamoebakeratitis. In cytomegalovirus corneal endotheliitis, a two-dimensional reconstruction map of the owl’s eye cells was created using acquired confocal images; the maps showed circular patterns. Also, we demonstrated that there is an association between owl’s eye cells observed by confocal microscopy and coin-shaped lesions observed by slit-lampbiomicroscopy. In patients with persistence of Acanthamoeba keratitis, invasion of cysts into Bowman’s layer was characteristically observed. This finding suggests that invasion of Acanthamoeba cysts into Bowman’s layer may be a useful predictor for a persistent clinical course.