Analysis of the host factor which is important for ovarian cancer dissemination

本研究旨在探讨SDF-1在卵巢癌腹膜转移中的作用。卵巢癌模型小鼠腹水中基质细胞衍生因子-1（SDF-1）表达增加。SDF-1促进卵巢癌细胞系的体外粘附和侵袭。免疫组化显示SDF-1主要由血管周细胞或成纤维细胞及肿瘤细胞分泌。SDF-1中和抗体延迟晚期卵巢癌模型小鼠的肿瘤生长并延长生存期。

This study was focused on the effect of SDF-1 on the ovarian cancer peritoneal dissemination. Stromal cell derived factor-1 (SDF-1) increased in the ascites of ovarian cancer model mice. SDF-1 promoted adhesion and invasion of ovarian cancer cell lines in vitro. Immunostaining showed SDF-1 was secreted from vascular pericytes or fibroblasts and tumor of TOV21G cell line. SDF-1 neutralizing antibody delayed tumor growth of advanced ovarian cancer model mice and prolonged survival.