Investigation of the mechanisms involving BMP-2-induced inhibition of bone formation or niche formation at the bone marrow microenvironment.

BMP-2被广泛认为是一种成骨诱导剂，但与其在骨髓空间内的功能有关的结果相互矛盾。本研究旨在阐明BMP-2对骨髓间隙骨代谢环境的分子机制及影响。令人感兴趣的是，我们发现BMP-2抑制骨髓空间的骨形成。迄今为止，为了阐明这一机制，我们从免疫学的角度关注BMP-2的负反馈调节以及细胞和分子的相互作用。

BMP-2 is widely known as an osteogenic inducer, but conflicting results are related to its function inside the bone marrow space. This study aimed to clarify the molecular mechanisms and impact of BMP-2 on bone metabolism environment of the bone marrow space. Of great interest, we found that BMP-2 inhibits bone formation in bone marrow space. To date, in an attempt to elucidate this mechanism, we are focusing on BMP-2 negative feedback regulation as well as on cellular and molecular interactions from an immunological perspective.