Investigation of the role of SSEA-4 in human periodontal ligament stem cells

SSEA-4对人牙周膜干细胞作用的研究

• 批准号: 23890126
• 负责人: MURATA Satoko
• 金额: $ 1.91万
• 依托单位: Kochi University (2012)Okayama University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890126/
• 关键词: ヒト歯根膜細胞; Stage-specific embryonic antigen-4; Serine palmitoyltransferase; Glucosylceramide synthetase; SSEA-4; ISP-1; D-PDMP; ヒト歯根膜幹細胞

In the present study, we investigated whether SSEA-4 synthesis is involved in maintenance and differentiation of human periodontal ligament (PDL) stem cells. Our results demonstrated that the blockade of serine palmitoyltransferas and glucosylceramide synthetase ,which are involved in SSEA-4 synthesis, affected adipogenic/osteogenic potential of human PDL stem cells. Hence, SSEA-4 synthesis appears to be involved in maintenance and differentiation of human PDL stem cells.

在本研究中，我们研究了SSEA-4的合成是否参与人牙周韧带（PDL）干细胞的维持和分化。我们的研究结果表明，丝氨酸棕榈酰转移酶和葡萄糖神经酰胺合成酶的阻断，参与SSEA-4的合成，影响了人PDL干细胞的成脂/成骨潜能。因此，SSEA-4的合成似乎参与了人PDL干细胞的维持和分化。

项目成果

ロンベルグ症候群患者における歯の組織学的検討

龙伯格综合征患者牙齿的组织学检查

• 发表时间: 2011
• 作者: 川辺紀章;菅原康代
• 通讯作者: 菅原康代

Stage-specific embryonic antigen-4 is a marker of human deciduous periodontalligament stem cells

阶段特异性胚胎抗原4是人乳牙牙周膜干细胞的标志物

• 发表时间: 2012
• 作者: Kawanab N;Fukushim H;Murata S,Ishihara Y;Yanagit T;Balam TA;Yamashiro T
• 通讯作者: Yamashiro T

Stage-specific embryonic antigen-4 identifies human dental pulp stem cells

• DOI: 10.1016/j.yexcr.2012.01.008
• 发表时间: 2012-03-10
• 期刊: EXPERIMENTAL CELL RESEARCH
• 影响因子: 3.7
• 作者: Kawanabe, Noriaki;Murata, Satoko;Yamashiro, Takashi
• 通讯作者: Yamashiro, Takashi