A study for the application of inorganic polyphosphate in peri-implantitis treatment

无机聚磷酸盐[聚(P)]是一种正磷酸盐残基的线性聚合物，对牙龈卟啉单胞菌有抗菌作用，促进组织再生和骨形成。在本研究中，我检测了巨噬细胞中poly(P)对poly(P)在种植体周围炎治疗中的作用，发现poly(P)在革兰氏阴性菌细胞壁成分脂多糖的刺激下抑制诱导型一氧化氮合酶的表达和一氧化氮的释放。

Inorganic polyphosphate [poly(P)], a linear polymer of orthophosphate residues, has antibacterial effects against Porphyromonas gingivalis and promotes tissue regeneration and bone formation. In this study, I examined effects of poly(P) in macrophages for the application of poly(P) in peri-implantitis treatment, and found that poly(P) suppresses the expression of inducible nitric oxide synthase and the release of nitric oxide in macrophages stimulated by lipopolysaccharide, a cell wall component of Gram-negative bacteria.