Disruption of circadian rhythm in malignant cancer cells

此前，研究表明，小鼠胚胎干细胞（ES）和体细胞衍生的诱导多能干细胞（iPS）中没有可检测到的昼夜节律。这表明细胞分化与昼夜节律的组织密切相关。在这项研究中，我研究了人类癌细胞系昼夜节律的破坏是否与其恶性程度相关。结果表明，不同细胞系与人U2OS细胞、骨肉瘤细胞系的昼夜节律性存在差异。此外，我检查了维甲酸治疗对这些人类胶质母细胞瘤细胞系昼夜节律的影响。

Previously, it has been shown that there is no detectable circadian rhythm in mouse embryonic stem (ES) cells and induced pluripotent stem (iPS) cells derived from somatic cells with circadian oscillation. This suggest s that cellular differentiation has a highly correlation with organization of circadian rhythm. In this study, I investigated whether disruption of circadian rhythm in human cancer cell lines is correlated with its degree of malignancy. As a result, the circadian rhythmicity was varied based on cell lines comparing with human U2OS cells, osteosarcoma cell lines. Furthermore, I examined the effect of retinoic acid treatment to the circadian rhythm in these human glioblastoma cell lines.