Disruption of circadian rhythm in malignant cancer cells

恶性癌细胞昼夜节律的破坏

• 批准号: 23890180
• 负责人: UMEMURA Yasuhiro
• 金额: $ 2.08万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890180/
• 关键词: がん; 体内時計; ES 細胞; ES細胞

Previously, it has been shown that there is no detectable circadian rhythm in mouse embryonic stem (ES) cells and induced pluripotent stem (iPS) cells derived from somatic cells with circadian oscillation. This suggest s that cellular differentiation has a highly correlation with organization of circadian rhythm. In this study, I investigated whether disruption of circadian rhythm in human cancer cell lines is correlated with its degree of malignancy. As a result, the circadian rhythmicity was varied based on cell lines comparing with human U2OS cells, osteosarcoma cell lines. Furthermore, I examined the effect of retinoic acid treatment to the circadian rhythm in these human glioblastoma cell lines.

此前已有研究表明，小鼠胚胎干（ES）细胞和源自具有昼夜节律振荡的体细胞的诱导多能干（iPS）细胞中没有可检测到的昼夜节律。这表明细胞分化与昼夜节律的组织高度相关。在这项研究中，我研究了人类癌细胞系昼夜节律的破坏是否与其恶性程度相关。结果，与人U2OS细胞、骨肉瘤细胞系相比，昼夜节律因细胞系而异。此外，我还研究了视黄酸治疗对这些人胶质母细胞瘤细胞系昼夜节律的影响。

项目成果

Effect of cellular reprogramming factors on circadian molecular oscillation in mammals.

细胞重编程因子对哺乳动物昼夜节律分子振荡的影响。

• 发表时间: 2012
• 作者: 中村健一;高森啓史;中原 修;生田義明;黒木秀幸;中川茂樹;美馬浩介;岡部弘尚;新田英利;今井克憲;近本 亮;土居浩一;石河隆敏;別府 透;猪山賢一;馬場秀夫;Yasuhiro Umemura
• 通讯作者: Yasuhiro Umemura

Effect of cellular reprogramming factors on circadian molecular oscillation in mammals

细胞重编程因子对哺乳动物昼夜节律分子振荡的影响

• 发表时间: 2012
• 作者: 馬場文;飯降聖子;植村小夜子;松井陽子;原田恵美;Yasuhiro Umemura
• 通讯作者: Yasuhiro Umemura