Molecular mechanism of xerostomia through diazepam binding inhibitor (DBI) in rat salivary glands

本研究探讨了反复给予地西泮（DZP）对大鼠唾液腺中PAC 1-R和CYP 11 A1 mRNA表达的影响。本研究表明，DZP重复给药可增加大鼠唾液腺中PAC 1-R和CYP 11 A1 mRNA的表达，减少唾液分泌。这些结果表明，重复给药DZP刺激PAC 1-R和CYP 11 A1的表达，这可能导致DZP对唾液分泌的抑制作用增加。

In this study, we investigated the effects of repetitive administration of diazepam (DZP) on expression of PAC1-R and CYP11A1 mRNA in rat salivary glands. The present study has shown clearly that repetitive administration of DZP increased expression of PAC1-R and CYP11A1 mRNA and decreased secretion of saliva in rat salivary gland. These results suggest that repetitive administration of DZP stimulates PAC1-R and CYP11A1 expression, which may result in an increase in the suppressive effect of DZP on salivary secretion.