Molecular mechanisms of up-regulation of regulatory T cells induced by asbestos

石棉诱导调节性T细胞上调的分子机制

• 批准号: 23890237
• 负责人: MATSUZAKI Hidenori
• 金额: $ 2.08万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890237/
• 关键词: アスベスト; がん; 腫瘍免疫; 制御性 T 細胞; アポトーシス; 悪性中皮腫; 制御性T細胞; 転写因子; FOXO1; 免疫

We previously reported that MT-2 cells, model of regulatory T cells, showed resistance to high concentration of asbestos and up-regulation of IL-10 and TGFβ production after long-term exposure to low concentration of asbestos. In this study, we analyzed the involvement of transcription factors, FoxP3, NFAT and FoxO1, in change of functions of MT-2 cells induced by asbestos. It was revealed that long-term exposure to asbestos reduced expression of FoxP3 and FoxO1, and FoxO1 regulated apoptosis induced by asbestos. These results are important for elucidating the mechanism of up-regulation of regulatory T cell induced by asbestos.

我们先前报道，MT-2细胞作为调节性T细胞的模型，在长期暴露于低浓度石棉后，表现出对高浓度石棉的抵抗力，并上调IL-10和转化生长因子β的产生。在本研究中，我们分析了转录因子FoxP3、NFAT和FoxO1在石棉诱导的MT-2细胞功能改变中的作用。结果表明，长期接触石棉可降低FoxP3和FoxO1的表达，FoxO1对石棉诱导的细胞凋亡有调节作用。这些结果对于阐明石棉诱导调节性T细胞上调的机制具有重要意义。

项目成果

Effect of Asbestos Exposure on Differentiation of Cytotoxic T Lymphocytes in MLR of Human PBMCs.

石棉暴露对人 PBMC MLR 中细胞毒性 T 淋巴细胞分化的影响。

• 发表时间: 2013
• 期刊: Am. J. Respir. Cell Mol. Biol.
• 作者: Kumagai-Takei;N.;Nishimura;Y.;Maeda;M.;Hayashi;H.;Matsuzaki;H.;Lee;S.;Hiratsuka;J.;Otsuki;T.
• 通讯作者: T.

Suppressive effect of exposure to asbestos on cytotoxicity of human NK cells

接触石棉对人 NK 细胞细胞毒性的抑制作用

• 发表时间: 2012
• 作者: Hiroko Noto;Satoshi Muraki;Naoko Kumagai;能登 裕子;Iwatsuki K;Yasumitsu Nishimura
• 通讯作者: Yasumitsu Nishimura

IFN-Γ, GRANZYME B AND PERFORIN-POSITIVE CELLS OF CD8+ LYMPHOCYTES IN ASBESTOS-EXPOSED PEOPLE WITH PLEURAL PLAQUE

石棉暴露者胸膜斑块中的 IFN-γ、颗粒酶 B 和 CD8+ 淋巴细胞的穿孔素阳性细胞

• 发表时间: 2012
• 作者: 能登裕子 ;村木里志;Naoko Kumagai-Takei
• 通讯作者: Naoko Kumagai-Takei

Continuous exposure of asbestos decreases FoxO1 expression and it may accelerate cell cycle progression in Treg model cell line MT-2 cell

连续接触石棉会降低 FoxO1 表达，并可能加速 Treg 模型细胞系 MT-2 细胞的细胞周期进程

• 发表时间: 2012
• 作者: Matsuzaki;H;Masako Abe;平井陽至;松崎秀紀;Masako Abe;三宅智子;李 順姫;山本剛伸;武井直子;Iwatsuki K;西村泰光;Iwatsuki K;大槻 剛巳;山本 剛伸;Matsuzaki Hidenori;三宅 智子;Yoshiaki Kikkawa;Lee Suni
• 通讯作者: Lee Suni

Carbon nanotubes-indued decrease in cytotoxicity of NK cells with altered expression of NK cell-activating receptors

碳纳米管导致 NK 细胞的细胞毒性降低，并改变 NK 细胞激活受体的表达

• 发表时间: 2012
• 作者: Yuta Seki;Kunie Matsuoka;Sari Suzuki;Yuki Miyasaka;Yasuhiro Oshiba;Kenta Wada;Hirohide Takebayashi;Yoshiaki Kikkawa;神谷 浩二;Nishimura Yasumitsu
• 通讯作者: Nishimura Yasumitsu