Effects of forced-use of impaired forelimb on the reorganizationof corticospinal tract

强迫使用受损前肢对皮质脊髓束重组的影响

• 批准号: 24800054
• 负责人: ISHIDA Akimasa
• 金额: $ 1万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24800054/
• 关键词: リハビリテーション; 脳出血; 内包; CI 療法; 上肢機能; 皮質内微小刺激法; 神経可塑性; CI療法; 皮質脊髄路

The aim of the present study was to determine the effect of forced impaired limb use (FLU) on the reorganization of the residue motor circuit after internal capsule hemorrhage(ICH). Forelimb movements were not elicited at all by intracortical microstimulation (ICMS) in the ipsilesional motor cortex in ICH-received rats on day 1 after ICH. On day 10, ICMS-evoked movements were observed only from small area of the caudal forelimb area (CFA). Comparing the ICH-non-treated control, forelimb movements were elicited from larger area in the CFA and rostral forelimb area (RFA) in the ICH-FLU-treated group. The forelimb motor maps were further expanded in the CIMT -group at day 24. Behavioralassessments showed better recovery in the ICH-CIMT rats than in the ICH rats. Moreover, microinjection of muscimol (1 uM, 1 ul) into the newly-emerged “forelimb areas” of the CFA and RFA caused apparent impairment of the recovered forelimb movements.

本研究的目的是确定强迫受损肢体使用(Flu)对内囊出血(ICH)后残余运动回路重组的影响。脑出血后第1天，皮质内微刺激(ICMS)完全不能引起脑出血大鼠损毁运动皮质前肢运动。第10天，ICMS诱发的运动仅在尾侧前肢区(CFA)的一小部分被观察到。与脑出血非治疗对照组相比，脑出血治疗组的前肢运动发生在CFA和吻侧前肢区(RFA)较大的区域。24天时，CIMT组的前肢运动图进一步扩大。行为学评估显示ICH-CIMT大鼠的恢复情况好于ICH大鼠。此外，向CFA和RFA新出现的“前肢区”内微量注射蝇毒酚(1um，1ul)，可明显损害恢复的前肢运动。

项目成果

Effect of forced impaired forelimb use on glutamate receptor expression in the sensorimotor cortex and functional recovery after capsular hemorrhage in rats

强迫前肢使用受损对大鼠感觉运动皮层谷氨酸受体表达及包膜出血后功能恢复的影响

• 发表时间: 2013
• 作者: Ayako Hashizume;and Masaaki Kurosu;Nakajima T et al.;Akimasa Ishida
• 通讯作者: Akimasa Ishida

Effect of forced-use of impaired forelimb on cortical map reorganization after capsular hemorrhage in rats

强迫使用受损前肢对大鼠包膜出血后皮质图重组的影响

• 发表时间: 2013
• 作者: 石田章真,梅田達也;伊佐正,飛田秀樹
• 通讯作者: 伊佐正,飛田秀樹

Induction of NMDA receptor expression in the sensorimotor cortex by intensive use of impaired upper limb relates to functional recovery after capsular hemorrhage in rats

密集使用受损上肢诱导感觉运动皮层 NMDA 受体表达与大鼠包膜出血后功能恢复相关

• 发表时间: 2012
• 作者: Akimasa Ishida;Sachiyo Misumi;Tadashi Masuda;Kazuto Ishida;Hideki Hida
• 通讯作者: Hideki Hida

内包出血後の運動野体部位再現マップの縦断的解析:麻痺肢の集中使用が及ぼす影響とは.

内囊出血后运动皮层区域再现图的纵向分析：瘫痪肢体的密集使用有何影响？

• 发表时间: 2013
• 作者: 石田章真,梅田達也;伊佐正,石田和人;飛田秀樹
• 通讯作者: 飛田秀樹

Intensive use of impaired limb alters forelimb representation of affected motor cortex and facilitates functional recovery in rats with capsular hemorrhage

密集使用受损肢体会改变受影响运动皮层的前肢表现，并促进囊膜出血大鼠的功能恢复

• 发表时间: 2013
• 作者: 阿部晶子;石合純夫;小森規代;関理絵;太田久晶;Mitsunori Miyazaki;今野貴之;Akimasa Ishida
• 通讯作者: Akimasa Ishida