investigation of geometical distortion for image analysis and development of classification in alzheimer's disease

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Alzheimer's disease (Alzheimer disease: AD) is the most serious dementia to affect cognitive functions. AD therapeutic drugs have been developing in the world, but it is pointed out for the enforcement to entail a vast cost with long time when it becomes the clinical trial. Image analysis using the MRI is effective for a clinical investigation evaluation of Alzheimer's disease, however the geometric distortion in the image ill-affect the reliability of image analysis. In this study, I developed correction method of geometrical distortion to improve this problem and this findings promote clinical investigation enforcement.