Gold nanocluster-catalyzed environmentally benign bond formation

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From environmental point of view, waste-less methodologies are important through processes in organic synthesis. The character of gold nanocluster which can make the oxidations proceed with molecular oxygen was utilized, and the atom-economic C-C bond formation was accomplished in this study. In the presence of gold nanocluster Au:PVP and sodium carbonate under oxygen, reflux of the starting materials, or 2-(methyleneamino)ethanol derivatives afforded 2-oxazoline derivatives. The methodology might be applied to synthesis of bioactive compounds' fragments and synthesis of chiral ligands.