Characterization of condensin-mediated DNA damage response in plants

一种植物染色体蛋白复合物，凝聚素II，已知在减轻DNA损伤中起作用。然而，目前尚不清楚凝聚素II在DNA损伤反应中的作用机制。为了揭示凝聚素II在减轻DNA损伤中的详细功能，我们表征了拟南芥凝聚素II突变体。结果发现，拟南芥凝聚素II不太可能是DNA损伤修复所需的，但在全基因组染色质的高度压缩中起作用。这些发现表明，拟南芥凝聚素II被认为是物理保护DNA通过染色质的高度压缩。

A plant chromosomal protein complex, condensin II, is known to function in alleviating DNA damage. However, it is still unclear that how condensin II acts in DNA damage response. To reveal the detailed function of condensin II in the alleviation of DNA damage, we characterized Arabidopsis condensin II mutants. As a result, it was found that Arabidopsis condensin II is unlikely to be required for the DNA damage repair but functions in the high compaction of genome-wide chromatin. These findings indicate that Arabidopsis condensin II is considered to physically protect DNA through the high compaction of chromatin.