The elucidation of mechanisms for wound healing along with component changes of wound fluid to establish a new method of nursing care

据报道，水泡沫敷料可以将创面渗出物留在创面，促进创面愈合，但其分子机制尚不清楚。在本研究中，我们利用动物模型研究了水孔泡沫敷料对创面愈合的影响及其与渗出液中细胞因子和/或生长因子水平的浓度和成分变化有关的调节机制。在大鼠背侧皮肤造成两个全层创面，每个创面分别覆盖水泡沫敷料或薄膜敷料。采集伤口渗出液和伤口周围皮肤样本进行分析。我们认为HCF上调了创面渗出液中的瘦素水平，这些作用有助于创面愈合。

Hydrocellular foam dressing has been reported to keep wound exudate at wound surface and promote wound healing; however, the molecular mechanisms responsible for these effects remain unknown. In the present study, we used an animal model to examine the effect of hydrocellular foam dressing (HCF) on wound healing and its regulatory mechanisms related to the concentration and component changes in cytokine and /or growth factor levels in the exudate. Two full-thickness wounds were created in the dorsolateral skin of rats and each wound was covered with either a hydrocellular foam dressing or the film dressing. Wound exudate and periwound skin samples were collected to analyze. We suggested that HCF upregulated the leptin level in the exudate at wound surface, and these effects contribute to wound healing.