Effects of beta-adrenergic receptor signaling on occlusal disharmony-induced osteoporosis.

本研究选用5周龄C57BL/6J雄性小鼠。在我们的小鼠咬合不和谐模型中，使用复合树脂连续7天导致咬合垂直高度增加0.5 mm。咬合失调诱导后血清皮质酮水平明显升高。放射学分析显示腰椎和长骨存在骨量减少，外周定量计算机断层扫描显示胫骨和股骨的力学性能降低。

Five-week-old C57BL/6J male mice were used in this study. In our murine occlusal disharmony model, a 0.5 mm increase in the vertical height of the occlusion was induced for seven days by the use of a composite resin. The serum corticosterone levels were significantly increased after the induction of occlusal disharmony. Radiological analyses revealed the presence of osteopenia in the lumbar vertebrae and long bones, and a reduction of the mechanical properties in the tibiae and femurs was uncovered by peripheral quantitative computed tomography.