Antifibrotic effect and role of antibody to connective tissue growth factor in an animal model of scleroderma

结缔组织生长因子抗体在硬皮病动物模型中的抗纤维化作用和作用

• 批准号: 24890076
• 负责人: CHUJO Sonoko
• 金额: $ 1万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890076/
• 关键词: 強皮症; 線維化; CTGF

We investigated antifibrotic effect of antibody to connective tissue growth factor (CTGF) in an animal model of skin fibrosis. Anti-CTGF antibody reduced skin fibrosis in a bleomycin-induced scleroderma mouse model and a tight skin mouse. It suggested that anti-CTGF antibody is capable of blocking the development of skin fibrosis in an animal model not induced by exogenous application of growth factors.

我们研究了结缔组织生长因子（CTGF）抗体在皮肤纤维化动物模型中的抗纤维化作用。抗CTGF抗体在博来霉素诱导的硬皮病小鼠模型和紧皮小鼠中减少皮肤纤维化。这表明抗CTGF抗体能够在非由外源性应用生长因子诱导的动物模型中阻断皮肤纤维化的发展。