global genetic analysis of inflammatory bowel disease associated with primary immunodeficiency

粘膜相关不变T细胞(MAIT)在几种自身免疫性疾病中的作用最近已有报道，但在炎症性肠病(IBD)中的作用尚未被描述。本文分析了88例溃疡性结肠炎和68例克罗恩病患者外周血中MAIT细胞，以及5例溃疡性结肠炎和10例克罗恩病患者的肠粘膜中的MAIT细胞。IBD患者外周血和肠粘膜中MAIT细胞均显著减少。此外，与对照组相比，克罗恩病患者MAIT细胞产生IL-17的比例更高。这些结果提示MAIT细胞与IBD的病理生理学有关。

A role for mucosal associated invariant T (MAIT) cells has recently been reported in several autoimmune diseases, but contribution to inflammatory bowel disease (IBD) has yet to be described. Here, we analyzed the MAIT cells in the peripheral blood of 88 ulcerative colitis patients and 68 Crohn's disease patients, and intestinal mucosae of 5 ulcerative colitis disease patients and 10 Crohn's disease patients. MAIT cells are significantly reduced both in the peripheral blood and the intestinal mucosa of IBD patients. Furthermore, the proportion of MAIT cells producing IL-17 was higher in Crohn's disease patients compared to controls. These results suggest the association of MAIT cells with pathophysiology of IBD.