Development of novel therapeutics and elucidation of drug resistance mechanisms in oral squamous cell carcinoma

建立了口腔鳞癌顺铂耐药细胞系后，分析结果表明cIAP 2是一种凋亡抑制蛋白，在口腔鳞癌顺铂耐药中起重要作用。此外，我们已经报道了它是一个预后因素，5-FU敏感因子表达cIAP 2导致5-FU耐药的口腔鳞癌以前。提示cIAP 2可能是多药耐药的靶因子。通过靶向抑制cIAP 2在难治性OSCC患者中的表达，有可能增强放化疗的效果，提高生存率。这个结果目前正在写论文中。

After establishment of CDDP-resistant oral squamous cell carcinoma(OSCC) cell line, we have presented the importance of cIAP2 is an apoptosis inhibitory protein in CDDP resistance of OSCC in the analysis result. Further, we have reported that it is a prognostic factor and,5-FU-sensitive factor expression cIAP2 leads to 5-FU resistance in OSCC previously. These things indicate the possibility of cIAP2 is the target factor of multi-drug resistance. By targeting cIAP2 in OSCC patients refractory to suppress the expression, it may be possible to enhance the effect of chemo-radiation therapy and improve survival. This result is in the middle of writing paper as currently.